Folinic Acid BP
Composition : Foly Tablet : Each tablet contains Folinic Acid 15mg as Calcium Folinate Pentahydrate BP.
Foly Injection : Each vial (5ml) contains Folinic Acid 50mg as Calcium Folinate BP.
Foly 100 Injection : Each vial (10ml) contains Folinic Acid 100mg as Calcium Folinate BP.
Indications : It is indicated to diminish the toxicity and counteract the effect of impaired Methotrexate elimination, treat the Megaloblastic anemia due to folate deficiency, as in sprue, nutritional deficiency & treatment of the Megaloblastic anemia of pregnancy and infancy. Calcium Folinate injection is also used in combination with 5-fluorouracil in cytotoxic therapy.
Dosage and administration : Calcium folinate should not be mixed in the same infusion as fluorouracil as a precipitate may form. OralReduction of harmful effects of folic acid antagonists such as Methotrexate, Trimethoprimetc : The dose is usually one 15mg tablet every 6 hours for 2 to 3 days. Megaloblastic anemia : In the treatment of Megaloblastic anemia, the dose is one 15 mg tablet daily. Intravenous Advanced Colorectal Cancer : Folinic Acid is administered at 200mg/m2 by slow intravenous injection followed by 5-fluorouracil at 370 mg/m2 by intravenous injection. Or 20 mg/m2 by slow intravenous injection followed by 5-fluorouracil at 425 mg/m2 by intravenous injection. Treatment is repeated daily for 5 days.This 5 day treatment course may be repeated at 4 weeks interval, for 2 courses and then may repeated at 4-5 weekly intervals if the patient has recovered completely from the toxic effects of the prior treatment course. Folinic acid rescue after high dose Methotrexate Therapy : Calcium Folinate starts 24 hours after the beginning of the methotrexate infusion at dose of 15mg (10mg/m2) every 6 hours for 10 doses. IntramuscularFolate deficient megaloboastic anaemia : Up to 1 mg/day. Or, as directed by the registered physician.
Use in Pregnancy and Lactation : There are no adequate and well-controlled clinical studies conducted in pregnant or breastfeeding women. It is not known whether this drug is excreted in human milk. Because may drugs are excreted in human milk, caution should be exercised when Calcium Folinate is administered to a nursing mother.
Foly Tablet : Each box contains 2 x 14's tablets in blister pack.
Foly Injection : Each box contains 1 glass vial of 5 ml solution.
Foly 100 Injection : Each box contains 1 glass vial of 10 ml solution.
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